Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:

PKC alpha (Serine/threonine kinase)

Seq-ID:

P04409 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, zinc ion binding, protein binding	plasma membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	494	MCKEHMMDGVTTRTFCGTPDY	-	8349635	LTP	0.86	-	S_TKc	0.22	-	medium
T	495	CKEHMMDGVTTRTFCGTPDYI	-	8349635	LTP	1.00	-	S_TKc	0.22	-	medium
T	497	EHMMDGVTTRTFCGTPDYIAP	-	8349635	LTP	1.00	-	S_TKc	0.20	-	medium
S	657	NIDQSDFEGFSYVNPQFVHPI	-	9013603	LTP	0.84	-	S_TK_X	0.24	-	medium

Substrate:

PKC alpha (Serine/threonine kinase)

Seq-ID:

P17252 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62532   RBP1_HUMAN
MINT-2490678   RAC1_HUMAN
MINT-2833162   BRAF_HUMAN
MINT-2833275   KPCE_HUMAN
MINT-2833291   KS6A2_HUMAN
MINT-3973484   NCF1_HUMAN
MINT-4298329   NUMB_DROME
MINT-4300836   INADL_HUMAN
MINT-4507294   JAK1_HUMAN
MINT-4507312   TYK2_HUMAN
MINT-4507332   IF2A_HUMAN
MINT-4507367   JAK2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone kinase activity (H3-T6 specific), ATP binding, enzyme binding, zinc ion binding	plasma membrane, cytosol, endoplasmic reticulum	induction of apoptosis by extracellular signals, response to interleukin-1

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	195	PMDPNGLSDPYVKLKLIPDPK	-	18083107	HTP	0.91	-	C2	0.45	3GPE	6.11%
S	226	RSTLNPQWNESFTFKLKPSDK	-	17081983	HTP	0.23	-	C2	0.45	3GPE	70.49%
S	226	RSTLNPQWNESFTFKLKPSDK	-	17192257	HTP	0.23	-	C2	0.45	3GPE	70.49%
S	319	KLGPAGNKVISPSEDRKQPSN	-	17081983	HTP	0.18	-	-	0.68	-	-
S	319	KLGPAGNKVISPSEDRKQPSN	-	16964243	HTP	0.18	-	-	0.68	-	-
S	319	KLGPAGNKVISPSEDRKQPSN	-	18088087	HTP	0.18	-	-	0.68	-	-
T	497	EHMMDGVTTRTFCGTPDYIAP	-	17192257	HTP	1.00	-	S_TKc	0.20	-	-
T	501	DGVTTRTFCGTPDYIAPEIIA	-	17192257	HTP	1.00	-	S_TKc	0.14	-	-
T	638	KFFTRGQPVLTPPDQLVIANI	-	15314172	LTP	0.92	-	S_TK_X	0.36	-	-
T	638	KFFTRGQPVLTPPDQLVIANI	-	14581488	LTP	0.92	-	S_TK_X	0.36	-	-
T	638	KFFTRGQPVLTPPDQLVIANI	-	17192257	HTP	0.92	-	S_TK_X	0.36	-	-
S	657	NIDQSDFEGFSYVNPQFVHPI	PKC_alpha	8856079	LTP	0.84	-	S_TK_X	0.23	-	-
Y	658	IDQSDFEGFSYVNPQFVHPIL	SYK	12881490	LTP	0.55	-	S_TK_X	0.23	-	-
Y	658	IDQSDFEGFSYVNPQFVHPIL	-	17192257	HTP	0.55	-	S_TK_X	0.23	-	-

Substrate:

PKC alpha (Serine/threonine kinase)

Seq-ID:

P20444 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4545254 CLOCK_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent protein kinase C activity, ATP binding, zinc ion binding, protein binding	plasma membrane, mitochondrion, nucleus	positive regulation of protein amino acid phosphorylation, inactivation of MAPK activity, negative regulation of insulin receptor signaling pathway, negative regulation of cell proliferation, negative regulation of glucose import, cellular calcium ion homeostasis, neutrophil chemotaxis, positive regulation of inflammatory response, regulation of muscle contraction, induction of apoptosis by intracellular signals, induction of positive chemotaxis, regulation of the force of heart contraction, regulation of peptidyl-tyrosine phosphorylation, chondrocyte differentiation, negative regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	319	KLGPVGNKVISPSEDRKQPSN	-	17114649	HTP	0.16	-	-	0.65	-	medium
T	497	EHMMDGVTTRTFCGTPDYIAP	PKC_beta	15364915	LTP	1.00	-	S_TKc	0.20	-	medium
S	657	NIDQSDFEGFSYVNPQFVHPI	-	12881490	LTP	0.88	-	S_TK_X	0.23	-	medium
S	657	NIDQSDFEGFSYVNPQFVHPI	-	17141160	LTP	0.88	-	S_TK_X	0.23	-	medium
Y	658	IDQSDFEGFSYVNPQFVHPIL	SYK	12881490	LTP	0.55	-	S_TK_X	0.24	-	medium